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Management of malignant pleural mesothelioma: A French multicenter retrospective study (GFPC 0802 study)

BMC Cancer, ISSN: 1471-2407, Vol: 15, Issue: 1, Page: 857
2015
  • 34
    Citations
  • 0
    Usage
  • 29
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    34
    • Citation Indexes
      32
    • Clinical Citations
      1
      • PubMed Guidelines
        1
    • Policy Citations
      1
      • Policy Citation
        1
  • Captures
    29

Article Description

Background: Malignant pleural mesothelioma (MPM) is a rare disease with poor prognosis in spite of significant improvement in survival, due to new chemotherapy regimens. We describe here patients' profiles and management in daily practice in France. Methods: Observational retrospective study. Data were collected from medical files. All patients with histologically proven MPM diagnosed from January 2005 to December 2008 were included in the participating sites. Results: Four hundred and six patients were included in 37 sites: mean age 68.9±9.8years, male predominance (sex ratio 3.27), latency of the disease 45.7years, epithelioïd type 83%. Diagnosis was made using thoracoscopy in 80.8% of patients. Radical surgery was performed in 6.2% of cases. Chemotherapy was administered to 74.6% of patients. First line regimens consisted mainly of platinum+pemetrexed (91%) or pemetrexed alone (7%). Objective response rate was 17.2% and another 41.6% of patients experienced disease stabilization. Half of these patients underwent second line chemotherapy (platinium+pemetrexed 31.6%, pemetrexed alone 24.6%), resulting in a 6% response rate. Third-line chemotherapy (56 patients) yielded disease control in 5.4% of cases. Conclusions: The management of MPM in France is usually in accordance with guidelines. Response rates are somewhat lower than those described in clinical trials.

Bibliographic Details

C. Raynaud; L. Greillier; J. Mazieres; I. Monnet; C. Chouaid; B. Mastroianni; G. Robinet; G. Fraboulet; A. Dixmier; H. Berard; R. Lamy; J. Letreut; H. Lena; G. Oliviero; S. Botta; A. Vergnenegre; I. Borget

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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