Effects of neural stem cell transplantation in Alzheimer's disease models
Journal of Biomedical Science, ISSN: 1423-0127, Vol: 27, Issue: 1, Page: 29
2020
- 78Citations
- 153Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations78
- Citation Indexes78
- 78
- CrossRef3
- Captures153
- Readers153
- 153
- Mentions1
- News Mentions1
- 1
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Effects of neural stem cell transplantation in Alzheimer's disease models.
J Biomed Sci. 2020 Jan 27;27(1):29. Authors: Hayashi Y, Lin HT, Lee CC, Tsai KJ PubMed: 31987051 Submit Comment
Review Description
Currently there are no therapies for treating Alzheimer's disease (AD) that can effectively halt disease progression. Existing drugs such as acetylcholinesterase inhibitors or NMDA receptor antagonists offers only symptomatic benefit. More recently, transplantation of neural stem cells (NSCs) to treat neurodegenerative diseases, including AD, has been investigated as a new therapeutic approach. Transplanted cells have the potential to replace damaged neural circuitry and secrete neurotrophic factors to counter symptomatic deterioration or to alter lesion protein levels. However, since there are animal models that can recapitulate AD in its entirety, it is challenging to precisely characterize the positive effects of transplanting NSCs. In the present review, we discuss the types of mouse modeling system that are available and the effect in each model after human-derived NSC (hNSC) or murine-derived NSC (mNSC) transplantation. Taken together, results from studies involving NSC transplantation in AD models indicate that this strategy could serve as a new therapeutic approach.
Bibliographic Details
Springer Science and Business Media LLC
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