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Severely impaired microvascular reactivity in diabetic patients with an acute coronary syndrome

Cardiovascular Diabetology, ISSN: 1475-2840, Vol: 15, Issue: 1, Page: 66
2016
  • 20
    Citations
  • 0
    Usage
  • 19
    Captures
  • 0
    Mentions
  • 180
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    20
  • Captures
    19
  • Social Media
    180
    • Shares, Likes & Comments
      180
      • Facebook
        180

Article Description

Background: Microvascular function is impaired in patients with stable coronary artery disease. The aim was to study microvascular function in patients with diabetes and acute coronary syndrome (ACS). Methods: Microvascular function was evaluated in 83 patients by laser Doppler fluxmetry (LDF) [PU; perfusion unit, median (interquartile range)] measuring resting LDF and peak LDF following a six min heating of the skin to 44 °C at the foot, respectively. All patients with ACS and without previously known diabetes underwent oral glucose tolerance test. Thirty-nine patients with type 2 diabetes mellitus free from coronary artery disease served as controls. Results: Peak LDF was significantly (P = 0.03) lower in patients with ACS and diabetes (n = 22; 72 (52)) and diabetes without coronary artery disease (n = 39; 69 (51)) as compared to patients with ACS without diabetes (n = 46; 97 (60)), and patients without ACS (n = 15; 140 (121)), respectively. Patients with ACS (n = 68) had significantly (P = 0.04) lower peak LDF (92 (49)) as compared to patients without ACS (n = 15) (140 (121)). Conclusion: Microvascular reactivity is severely impaired in patients with diabetes and ACS. Diabetes has a major influence on microvascular function in patients with coronary artery disease.

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