Association between homocysteine and non-alcoholic fatty liver disease in Chinese adults: a cross-sectional study
Nutrition Journal, ISSN: 1475-2891, Vol: 15, Issue: 1, Page: 1-7
2016
- 34Citations
- 53Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations34
- Citation Indexes34
- 34
- CrossRef30
- Captures53
- Readers53
- 53
Article Description
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, and its prevalence is likely to rise even further. To help understand the pathogenesis and early prevention of progressive NAFLD, this large-scale study was designed to explore the potential association between homocysteine and the prevalence of NAFLD. Methods: A total of 7203 subjects aged 18 years or older were enrolled in this cross-sectional study. The association of homocysteine with the prevalence of NAFLD, in the total sample and stratified by subgroups, was examined using multiple logistic regression analyses. Results: Subjects in the higher quartiles of homocysteine had a higher prevalence of NAFLD. After multivariate adjustment, the odds ratio (OR) for NAFLD in the highest compared with the lowest quartile of homocysteine was 2.08 (95% confidence interval [CI] 1.61, 2.67). Moreover, in the subgroup analyses, we found an effect modification by gender, body mass index (BMI) and smoking status on the association between homocysteine and the prevalence of NAFLD (P for interaction: 0.001, 0.002 and <0.001, respectively). A stronger association was observed in female, obese and non-smoking adults than in male, normal weight and smoking subjects. Conclusion: Homocysteine was significantly associated with the prevalence of NAFLD, particularly in female, obese or non-smoking adults.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85003914582&origin=inward; http://dx.doi.org/10.1186/s12937-016-0221-6; http://www.ncbi.nlm.nih.gov/pubmed/27955646; http://nutritionj.biomedcentral.com/articles/10.1186/s12937-016-0221-6; https://dx.doi.org/10.1186/s12937-016-0221-6; https://nutritionj.biomedcentral.com/articles/10.1186/s12937-016-0221-6
Springer Science and Business Media LLC
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