PlumX Metrics
Embed PlumX Metrics

Rational design of NIR-II molecule-engineered nanoplatform for preoperative downstaging and imaging-guided surgery of orthotopic hepatic tumor

Journal of Nanobiotechnology, ISSN: 1477-3155, Vol: 21, Issue: 1, Page: 489
2023
  • 0
    Citations
  • 0
    Usage
  • 1
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Captures
    1
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Studies from University of South China Update Current Data on Liver Cancer (Rational Design of Nir-ii Molecule-engineered Nanoplatform for Preoperative Downstaging and Imaging-guided Surgery of Orthotopic Hepatic Tumor)

2024 JAN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Daily News -- Investigators publish new report on Oncology - Liver

Article Description

Orthotopic advanced hepatic tumor resection without precise location and preoperative downstaging may cause clinical postoperative recurrence and metastasis. Early accurate monitoring and tumor size reduction based on the multifunctional diagnostic-therapeutic integration platform could improve real-time imaging-guided resection efficacy. Here, a Near-Infrared II/Photoacoustic Imaging/Magnetic Resonance Imaging (NIR-II/PAI/MRI) organic nanoplatform IRFEP-FA-DOTA-Gd (IFDG) is developed for integrated diagnosis and treatment of orthotopic hepatic tumor. The IFDG is designed rationally based on the core “S-D-A-D-S” NIR-II probe IRFEP modified with folic acid (FA) for active tumor targeting and Gd-DOTA agent for MR imaging. The IFDG exhibits several advantages, including efficient tumor tissue accumulation, good tumor margin imaging effect, and excellent photothermal conversion effect. Therefore, the IFDG could realize accurate long-term monitoring and photothermal therapy non-invasively of the hepatic tumor to reduce its size. Next, the complete resection of the hepatic tumor in situ lesions could be realized by the intraoperative real-time NIR-II imaging guidance. Notably, the preoperative downstaging strategy is confirmed to lower the postoperative recurrence rate of the liver cancer patients under middle and advanced stage effectively with fewer side effects. Overall, the designed nanoplatform demonstrates great potential as a diagnostic-therapeutic integration platform for precise imaging-guided surgical navigation of orthotopic hepatic tumors with a low recurrence rate after surgery, providing a paradigm for diagnosing and treating the advanced tumors in the future clinical translation application. Graphical Abstract: [Figure not available: see fulltext.].

Bibliographic Details

Pan, Qi; Li, Ke; Kang, Xueqin; Li, Kaixuan; Cheng, Zihe; Wang, Yafei; Xu, Yuye; Li, Lei; Li, Na; Wu, Guilong; Yang, Sha; Qi, Shuo; Chen, Guodong; Tan, Xiaofeng; Zhan, Yonghua; Tang, Li; Zhan, Wenhua; Yang, Qinglai

Springer Science and Business Media LLC

Chemical Engineering; Medicine; Biochemistry, Genetics and Molecular Biology; Engineering; Immunology and Microbiology; Pharmacology, Toxicology and Pharmaceutics

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know