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Reduced cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with low b-value diffusion weighted imaging

Fluids and Barriers of the CNS, ISSN: 2045-8118, Vol: 21, Issue: 1, Page: 40
2024
  • 1
    Citations
  • 0
    Usage
  • 7
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

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  • Citations
    1
  • Captures
    7
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Research on Parkinson's Disease Discussed by Researchers at Vanderbilt University Medical Center (Reduced cerebrospinal fluid motion in patients with Parkinson's disease revealed by magnetic resonance imaging with low b-value diffusion weighted ...)

2024 MAY 23 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Daily News -- A new study on Parkinson's disease is now

Article Description

Background: Parkinson’s disease is characterized by dopamine-responsive symptoms as well as aggregation of α-synuclein protofibrils. New diagnostic methods assess α-synuclein aggregation characteristics from cerebrospinal fluid (CSF) and recent pathophysiologic mechanisms suggest that CSF circulation disruptions may precipitate α-synuclein retention. Here, diffusion-weighted MRI with low-to-intermediate diffusion-weightings was applied to test the hypothesis that CSF motion is reduced in Parkinson’s disease relative to healthy participants. Methods: Multi-shell diffusion weighted MRI (spatial resolution = 1.8 × 1.8 × 4.0 mm) with low-to-intermediate diffusion weightings (b-values = 0, 50, 100, 200, 300, 700, and 1000 s/mm) was applied over the approximate kinetic range of suprasellar cistern fluid motion at 3 Tesla in Parkinson’s disease (n = 27; age = 66 ± 6.7 years) and non-Parkinson’s control (n = 32; age = 68 ± 8.9 years) participants. Wilcoxon rank-sum tests were applied to test the primary hypothesis that the noise floor-corrected decay rate of CSF signal as a function of b-value, which reflects increasing fluid motion, is reduced within the suprasellar cistern of persons with versus without Parkinson’s disease and inversely relates to choroid plexus activity assessed from perfusion-weighted MRI (significance-criteria: p < 0.05). Results: Consistent with the primary hypothesis, CSF decay rates were higher in healthy (D = 0.00673 ± 0.00213 mm/s) relative to Parkinson’s disease (D = 0.00517 ± 0.00110 mm/s) participants. This finding was preserved after controlling for age and sex and was observed in the posterior region of the suprasellar cistern (p < 0.001). An inverse correlation between choroid plexus perfusion and decay rate in the voxels within the suprasellar cistern (Spearman’s-r=-0.312; p = 0.019) was observed. Conclusions: Multi-shell diffusion MRI was applied to identify reduced CSF motion at the level of the suprasellar cistern in adults with versus without Parkinson’s disease; the strengths and limitations of this methodology are discussed in the context of the growing literature on CSF flow.

Bibliographic Details

Pierobon Mays, Gabriela; Hett, Kilian; Eisma, Jarrod; McKnight, Colin D; Elenberger, Jason; Song, Alexander K; Considine, Ciaran; Richerson, Wesley T; Han, Caleb; Stark, Adam; Claassen, Daniel O; Donahue, Manus J

Springer Science and Business Media LLC

Neuroscience

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