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Rare entities in head-and-neck cancer: Salvage re-irradiation with carbon ions

Radiation Oncology, ISSN: 1748-717X, Vol: 14, Issue: 1, Page: 202
2019
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Article Description

Background: The objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There is a paucity of data regarding treatment approaches in this patient cohort, which we aim to address in this work. Methods: Thirty-two (n = 32) consecutive patients with uncommon HNC treated between 2010 and 2017 were retrospectively analyzed in terms of clinical outcomes, patterns of failure, and toxicity. Results: Mucoepidermoid carcinoma (MEC) was the most common histology (22%). Patients received a median cumulative dose equivalent in 2 Gy fractions (EQD) after CIR of 128.6 Gy (range, 105.8-146.5 Gy). The local and distant control rates 1 year after CIR were 66 and 72%. No serious acute or late toxicity (≥ grade 3) after CIR was observed. Conclusions: CIR may represent an effective and safe treatment alternative to palliative systemic therapies in these rare indications.

Bibliographic Details

Held, Thomas; Windisch, Paul; Akbaba, Sati; Lang, Kristin; Farnia, Benjamin; Liermann, Jakob; Bernhardt, Denise; Plinkert, Peter; Freudlsperger, Christian; Rieken, Stefan; Herfarth, Klaus; Debus, Jürgen; Adeberg, Sebastian

Springer Science and Business Media LLC

Medicine

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