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Changes over time in callus formation caused by intermittently administering PTH in rabbit distraction osteogenesis models

Journal of Orthopaedic Surgery and Research, ISSN: 1749-799X, Vol: 10, Issue: 1, Page: 88
2015
  • 12
    Citations
  • 0
    Usage
  • 19
    Captures
  • 0
    Mentions
  • 168
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    12
  • Captures
    19
  • Social Media
    168
    • Shares, Likes & Comments
      168
      • Facebook
        168

Article Description

Background: Changes over time in the callus during intermittent administration of parathyroid hormone (PTH) were studied in rabbit distraction osteogenesis models. Method: Models of distraction osteogenesis in Japanese white rabbits were created, and distraction osteogenesis (total length: 10.5 mm) was performed for 2 weeks. Simultaneously with the start of distraction, 30 rabbits received 4 weeks of subcutaneous administration of 30 μg/kg of PTH(1-34), teriparatide, (P-group: n = 15) or saline (N-group: n = 15) every other day. The tibias of five rabbits were dissected at 6, 8, and 10 weeks after surgery to perform bone mineral density (BMD), peripheral quantitative computed tomography (pQCT), and mechanical testing. Results: The mean BMD had no significant differences over time at 6, 8, and 10 weeks after surgery between the P-group and the N-group. On pQCT, the P-group had significant increases in total bone cross-sectional area of the callus compared to the N-group at 8 and 10 weeks after surgery. On mechanical testing, the P-group's absorption energy had not changed at 6 weeks after surgery compared to the N-group, but it had significantly increased at 8 weeks. At 10 weeks after surgery, the N-group's absorption energy rapidly increased, and the difference between the two groups disappeared. Conclusion: The intermittent administration of PTH(1-34), teriparatide, for 4 weeks every other day from the start of distraction had the potential to shorten the callus maturation period in the rabbit distraction osteogenesis models.

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