PlumX Metrics
Embed PlumX Metrics

Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma

Journal of Hematology and Oncology, ISSN: 1756-8722, Vol: 9, Issue: 1, Page: 48
2016
  • 31
    Citations
  • 0
    Usage
  • 31
    Captures
  • 0
    Mentions
  • 634
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    31
  • Captures
    31
  • Social Media
    634
    • Shares, Likes & Comments
      634
      • Facebook
        634

Article Description

Background: Ewing sarcoma (EWS) is a malignant tumour of bone and soft tissue, and although many patients are cured with conventional multimodal therapy, those with recurrent or metastatic disease have a poor prognosis. Genomic instability and programmed cell death ligand-1 (PD-L1) expression have been identified in EWS, providing a rationale for treatment with agents that block the programmed cell death-1 (PD-1) receptor. Case presentation: In this report, we describe a heavily pre-treated patient with recurrent metastatic EWS who achieved a clinical and radiological remission with PD-1 blockade. Conclusions: To our knowledge, this is the first reported case demonstrating efficacy of PD-1 blockade in EWS. This warrants further investigation in particular given the poor prognosis in patients with recurrent or metastatic disease.

Bibliographic Details

McCaughan, Georgia J B; Fulham, Michael J; Mahar, Annabelle; Soper, Judy; Hong, Angela M; Stalley, Paul D; Tattersall, Martin H N; Bhadri, Vivek A

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know