Quantitative assessment of preoperative brain development in pediatric congenital heart disease patients by synthetic MRI
Insights into Imaging, ISSN: 1869-4101, Vol: 15, Issue: 1, Page: 166
2024
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Most Recent News
Gansu Provincial Maternity and Child-Care Hospital Reports Findings in Congenital Heart Disease (Quantitative assessment of preoperative brain development in pediatric congenital heart disease patients by synthetic MRI)
2024 JUL 12 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Daily News -- New research on Congenital Diseases and Conditions - Congenital
Article Description
Objectives: This study investigated the quantitative assessment and application of Synthetic MRI (SyMRI) for preoperative brain development in children with congenital heart disease (CHD). Methods: Forty-three CHD patients aged 2–24 months were prospectively included in the observation group, and 43 healthy infants were included in the control group. The SyMRI scans were processed by postprocessing software to obtain T1, T2, and PD maps. The values of T1, T2, and PD in different brain regions were compared with the scores of the five ability areas of the Gesell Development Scale by Pearson correlation analysis. Results: In the observation group, the T1 values of the posterior limb of the internal capsule (PLIC), Optic radiation (PTR), cerebral peduncle, centrum semiovale, occipital white matter, temporal white matter, and dentate nucleus were greater than those in the control group. In the observation group, the T2 values of the PLIC, PTR, frontal white matter, occipital white matter, temporal white matter, and dentate nucleus were greater than those in the control group. Pearson correlation analysis revealed that the observation group had significantly lower Development Scale scores. In the observation group, the T2 value of the splenium of the corpus callosum was significantly positively correlated with the personal social behavior score. The AUCs for diagnosing preoperative brain developmental abnormalities in children with CHD using T1 values of the temporal white matter and dentate nucleus were both greater than 0.60. Conclusions: Quantitative assessment using SyMRI can aid in the early detection of preoperative brain development abnormalities in children with CHD. Critical relevance statement: T1 and T2 relaxation values from SyMRI can be considered as a quantitative imaging marker to detect abnormalities, allowing for early clinical evaluation and timely intervention, thereby reducing neurodevelopmental disorders in these children. Key Points: T1 and T2 relaxation values by SyMRI are related to myelin development. Evaluated development quotient markers were lower in the observation compared to the control group. SyMRI can act as a reference indicator for brain development in CHD children. Graphical Abstract: (Figure presented.)
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85197588022&origin=inward; http://dx.doi.org/10.1186/s13244-024-01746-0; http://www.ncbi.nlm.nih.gov/pubmed/38954290; https://insightsimaging.springeropen.com/articles/10.1186/s13244-024-01746-0; https://dx.doi.org/10.1186/s13244-024-01746-0
Springer Science and Business Media LLC
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