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Targeted antiangiogenic agents in combination with cytotoxic chemotherapy in preclinical and clinical studies in sarcoma.

Clinical sarcoma research, ISSN: 2045-3329, Vol: 6, Issue: 1, Page: 9
2016
  • 6
    Citations
  • 0
    Usage
  • 23
    Captures
  • 1
    Mentions
  • 26
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    6
  • Captures
    23
  • Mentions
    1
    • Blog Mentions
      1
      • 1
  • Social Media
    26
    • Shares, Likes & Comments
      26
      • Facebook
        26

Most Recent Blog

Antiangiogenic Inhibition of Angiosarcomas both Conventionally and Non-Conventionally

studies have demonstrated that inhibition of angiogenic pathways or disruption of established vasculature can attenuate the growth of sarcomas Angio sarcomas are a rare and

Review Description

Sarcomas are a heterogeneous group of mesenchymal malignancies. In recent years, studies have demonstrated that inhibition of angiogenic pathways or disruption of established vasculature can attenuate the growth of sarcomas. However, when used as monotherapy in the clinical setting, these targeted antiangiogenic agents have only provided modest survival benefits in some sarcoma subtypes, and have not been efficacious in others. Preclinical and early clinical data suggest that the addition of conventional chemotherapy to antiangiogenic agents may lead to more effective therapies for patients with these tumors. In the current review, the authors summarize the available evidence and possible mechanisms supporting this approach.

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