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Multiwalled carbon nanotubes decorated with bismuth (III) oxide for electrochemical detection of an antipyretic and analgesic drug paracetamol in biological samples

Journal of Analytical Science and Technology, ISSN: 2093-3371, Vol: 10, Issue: 1
2019
  • 24
    Citations
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  • 35
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Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    24
    • Citation Indexes
      24
  • Captures
    35

Article Description

Background: In the present work, an electrochemical sensor for detection of paracetamol was fabricated by modifying a glassy carbon electrode (GCE) using multiwalled carbon nanotube (MWCNT) decorated with bismuth oxide (BiO) based on using the drop dry technique. Methods: The prepared composite electrode was characterized by scanning electron microscopy–energy dispersive X-ray spectroscopy (SEM–EDS), Fourier transform infrared spectroscopy (FT-IR), and cyclic voltammetry (CV). Electrochemical techniques such as cyclic voltammetry, chronoamperometry, and square wave voltammetry (SWV) were used to study the behavior of paracetamol. Results: The modification process improved the redox kinetics of paracetamol as shown by increased peak currents. The peak current varied linearly with increment of paracetamol concentration in the range of 0.02 to 28 μM with a sensitivity of 1.133 μA μM. A detection limit of 0.0052 μM was obtained. Conclusion: The proposed method was successfully applied to determination of paracetamol in biological samples with recoveries in the range 94.3–98.7%.

Bibliographic Details

Arthur T. Chipeture; Daniel Apath; Mambo Moyo; Munyaradzi Shumba

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology; Chemistry; Environmental Science; Materials Science; Physics and Astronomy

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