Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages
Journal of Leukocyte Biology, ISSN: 0741-5400, Vol: 85, Issue: 2, Page: 268-277
2009
- 69Citations
- 64Captures
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Metrics Details
- Citations69
- Citation Indexes69
- 69
- CrossRef65
- Captures64
- Readers64
- 64
Article Description
The metabolism of the amino acid L-arginine is emerging as a crucial mechanism for the regulation of immune responses. Here, we characterized the impact of L-arginine deprivation on T cell and macrophage (MΦ) effector functions: We show that whereas L-arginine is required unconditionally for T cell activation, MΦ can up-regulate activation markers and produce cytokines and chemokines in the absence of L-arginine. Furthermore, we show that L-arginine deprivation does not affect the capacity of activated MΦ to up-regulate L-arginine-metabolizing enzymes such as inducible NO synthase and arginase 1. Thus, our results show that to exert their effector functions, T cells and MΦ have different requirements for L-arginine. © Society for Leukocyte Biology.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=59649127762&origin=inward; http://dx.doi.org/10.1189/jlb.0508310; http://www.ncbi.nlm.nih.gov/pubmed/19008294; https://academic.oup.com/jleukbio/article/85/2/268/6975074; http://www.jleukbio.org/cgi/doi/10.1189/jlb.0508310; http://www.jleukbio.org/content/85/2/268.short
Oxford University Press (OUP)
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