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Transcriptional regulation of myeloid-derived suppressor cells

Journal of Leukocyte Biology, ISSN: 1938-3673, Vol: 98, Issue: 6, Page: 913-922
2015
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Most Recent News

Ferroptosis of tumour neutrophils causes immune suppression in cancer

Nature, Published online: 16 November 2022; doi:10.1038/s41586-022-05443-0 Pathologically activated neutrophils, termed myeloid-derived suppressor cells, in the tumour microenvironment spontaneously undergo ferroptosis, which negatively regulates anti-tumour immunity through the release of oxygenated lipids, therefore limiting the activity of human and mouse T cells.

Review Description

Myeloid-derived suppressor cells are a heterogeneous group of pathologically activated immature cells that play a major role in the negative regulation of the immune response in cancer, autoimmunity, many chronic infections, and inflammatory conditions, as well as in the regulation of tumor angiogenesis, tumor cell invasion, and metastases. Accumulation of myeloid-derived suppressor cells is governed by a network of transcriptional regulators that could be combined into 2 partially overlapping groups: factors promoting myelopoiesis and preventing differentiation of mature myeloid cells and factors promoting pathologic activation of myeloidderived suppressor cells. In this review, we discuss the specific nature of these factors and their impact on myeloid-derived suppressor cell development.

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