ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I
Journal of Lipid Research, ISSN: 0022-2275, Vol: 45, Issue: 4, Page: 635-644
2004
- 123Citations
- 45Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations123
- Citation Indexes123
- 123
- CrossRef94
- Captures45
- Readers45
- 45
- Mentions1
- News Mentions1
- News1
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Article Description
Prior studies provide data supporting the notion that ATP binding cassette transporter A1 (ABCA1) promotes lipid efflux to extracellular acceptors in a two-step process: first, ABCA1 mediates phospholipid efflux to an apolipoprotein, and second, this apolipoprotein-phospholipid complex accepts free cholesterol in an ABCA1-independent manner. In the current study using RAW264.7 cells, ABCA1-mediated free cholesterol and phospholipid efflux to apolipoprotein A-I (apoA-I) were tightly coupled to each other both temporally and after treatment with ABCA1 inhibitors. The time course and temperature dependence of ABCA1-mediated lipid efflux to apoA-I support a role for endocytosis in this process. Cyclodextrin treatment of RAW264.7 cells partially inhibited 8Br-cAMP-induced efflux of free cholesterol and phospholipid to apoA-I. ABCA1-expressing cells are more sensitive to cell damage by high-dose cyclodextrin and vanadate, leading to increased lactate dehydrogenase leakage and phospholipid release even in the absence of the acceptor apoA-I. Finally, we could not reproduce a two-step effect on lipid efflux using conditioned medium from ABCA1-expressing cells pretreated with cyclodextrin.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0022227520318472; http://dx.doi.org/10.1194/jlr.m300336-jlr200; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1642547065&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/14703508; http://www.jlr.org/lookup/doi/10.1194/jlr.M300336-JLR200; https://syndication.highwire.org/content/doi/10.1194/jlr.M300336-JLR200; https://linkinghub.elsevier.com/retrieve/pii/S0022227520318472; https://dx.doi.org/10.1194/jlr.m300336-jlr200
American Society for Biochemistry & Molecular Biology (ASBMB)
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