PlumX Metrics
Embed PlumX Metrics

Simplified Geriatric Assessment in Older Patients With Diffuse Large B-Cell Lymphoma: The Prospective Elderly Project of the Fondazione Italiana Linfomi

Journal of Clinical Oncology, ISSN: 1527-7755, Vol: 39, Issue: 11, Page: 1214-1222
2021
  • 103
    Citations
  • 0
    Usage
  • 82
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Most Recent News

Simplified Geriatric Assessment Validated as OS Predictor in Elderly Patients With DLBCL

A simplified geriatric assessment offers a validated objective tool to assess fitness status and should be considered the new Elderly Prognostic Index (EPI) standard to

Article Description

PURPOSE To prospectively validate the use of a simplified geriatric assessment (sGA) at diagnosis and to integrate it into a prognostic score for older patients with diffuse large B-cell lymphoma (DLBCL). METHODS We conducted the prospective Elderly Project study on patients with DLBCL older than 64 years who underwent our Fondazione Italiana Linfomi original geriatric assessment (oGA) (age, Cumulative Illness Rating Scale for Geriatrics, activities of daily living, and instrumental activities of daily living) before treatment. Treatment choice was left to the physician’s discretion. The primary end point was overall survival (OS) (ClinicalTrials.gov identifier: NCT02364050). RESULTS We analyzed 1,163 patients (median age 76 years), with a 3-year OS of 65% (95% CI, 62 to 68). Because at multivariate analysis on oGA, age > 80 years retained an independent correlation with OS, we also developed a new, simplified version of the GA (sGA) that classifies patients as fit (55%), unfit (28%), and frail (18%) with significantly different 3-year OS of 75%, 58%, and 43%, respectively. The sGA groups, International Prognostic Index, and hemoglobin levels were independent predictors of OS and were used to build the Elderly Prognostic Index (EPI). Three risk groups were identified: low (23%), intermediate (48%), and high (29%), with an estimated 3-year OS of 87% (95% CI, 81 to 91), 69% (95% CI, 63 to 73), and 42% (95% CI, 36 to 49), respectively. The EPI was validated using an independent external series of 328 cases. CONCLUSION The Elderly Project validates sGA as an objective tool to assess fitness status and defines the new EPI to predict OS of older patients with DLBCL.

Bibliographic Details

Merli, Francesco; Luminari, Stefano; Tucci, Alessandra; Arcari, Annalisa; Rigacci, Luigi; Hawkes, Eliza; Chiattone, Carlos S; Cavallo, Federica; Cabras, Giuseppina; Alvarez, Isabel; Fabbri, Alberto; Re, Alessandro; Puccini, Benedetta; Barraclough, Allison; Delamain, Marcia Torresan; Ferrero, Simone; Usai, Sara Veronica; Ferrari, Angela; Cencini, Emanuele; Pennese, Elsa; Zilioli, Vittorio Ruggero; Marino, Dario; Balzarotti, Monica; Cox, Maria Christina; Zanni, Manuela; Di Rocco, Alice; Lleshi, Arben; Botto, Barbara; Hohaus, Stefan; Merli, Michele; Sartori, Roberto; Gini, Guido; Nassi, Luca; Musuraca, Gerardo; Tani, Monica; Bottelli, Chiara; Kovalchuk, Sofia; Re, Francesca; Flenghi, Leonardo; Molinari, Annalia; Tarantini, Giuseppe; Chimienti, Emanuela; Marcheselli, Luigi; Mammi, Caterina; Spina, Michele

American Society of Clinical Oncology (ASCO)

Medicine; Biochemistry, Genetics and Molecular Biology

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know