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Cell-Penetrating Peptides as Passive Permeation Enhancers for Transdermal Drug Delivery

AAPS PharmSciTech, ISSN: 1530-9932, Vol: 23, Issue: 7, Page: 266
2022
  • 16
    Citations
  • 0
    Usage
  • 18
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  • 2
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

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Article Description

Cell-penetrating peptides have been widely used as a tool to gain access to cytosol for numerous applications. The review highlights the advances made in preclinical and clinical research using cell-penetrating peptides since their discovery in 1980s. Further, the emphasis is on summarizing the role of cell-penetrating peptides as permeation enhancers for transdermal and topical drug delivery applications. A summary table of preclinical studies utilizing various peptides in combination with different active ingredients and drug delivery systems is included. Lastly, we capture the challenges associated with the cell-penetrating peptides to translate the preclinical work to clinical applications.

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