Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease
Endocrinology, ISSN: 0013-7227, Vol: 147, Issue: 2, Page: 754-761
2006
- 52Citations
- 73Captures
- 5Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations52
- Citation Indexes52
- 52
- CrossRef41
- Captures73
- Readers73
- 42
- 30
- Mentions5
- References5
- Wikipedia5
Article Description
We examined the relationship among relaxin (a peptide hormone that stimulates collagen degradation), airway fibrosis, other changes of airway remodeling, and airway hyperresponsiveness (AHR) in an animal model of allergic airway disease. Eight- to 10-wk-old relaxin gene-knockout (RLX) and wild-type (RLX) mice were sensitized with ovalbumin (OVA) or saline ip at d 0 and 14 and challenged three times per week for 6 wk with nebulized 2.5% OVA or saline. Saline-treated control RLX and RLX mice had equivalent collagen expression and baseline airway responses. OVA-treated RLX mice developed airway inflammation equivalent to that in OVA-treated RLX mice. However, OVA-treated RLX mice had markedly increased lung collagen deposition as compared with OVA-treated RLX and saline-treated mice (all P < 0.05). Collagen was predominantly deposited in the subepithelial basement membrane region and submucosal regions in both OVA-treated RLX and RLX mice. The increased collagen measured in OVA-treated RLX mice was associated with reduced matrix metalloproteinase (MMP)-9 (P < 0.02) expression and failure to up-regulate matrix metalloproteinase-2 expression, compared with levels in OVA-treated RLX mice. Goblet cell numbers were equivalent in OVA-treated RLX and RLX mice and increased, compared with saline-treated animals. Both OVA-treated RLX and RLX mice developed similar degrees of AHR after OVA treatment. These findings demonstrate a critical role for relaxin in the inhibition of lung collagen deposition during an allergic inflammatory response. Increased deposition of collagen per se did not influence airway epithelial structure or AHR. Copyright © 2006 by The Endocrine Society.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=30944442868&origin=inward; http://dx.doi.org/10.1210/en.2005-1006; http://www.ncbi.nlm.nih.gov/pubmed/16254028; https://academic.oup.com/endo/article/147/2/754/2500267; https://dx.doi.org/10.1210/en.2005-1006; https://academic.oup.com/endo/article-abstract/147/2/754/2500267?redirectedFrom=fulltext
The Endocrine Society
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know