Role of Agouti-related protein-expressing neurons in lactation
Endocrinology, ISSN: 0013-7227, Vol: 149, Issue: 2, Page: 544-550
2008
- 21Citations
- 29Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations21
- Citation Indexes21
- 21
- CrossRef18
- Captures29
- Readers29
- 29
Article Description
Hypothalamic neurons that express agouti-related protein (AgRP) and neuropeptide Y (NPY) are thought to be important for regulation of feeding, especially under conditions of negative energy balance. The expression of NPY and AgRP increases during lactation and may promote the hyperphagia that ensues. We explored the role of AgRP neurons in reproduction and lactation, using a mouse model in which AgRP-expressing neurons were selectively ablated by the action of diphtheria toxin. We show that ablation of AgRP neurons in neonatal mice does not interfere with pregnancy, parturition, or lactation, suggesting that early ablation allows compensatory mechanisms to become established. However, ablation of AgRP neurons after lactation commences results in rapid starvation, indicating that both basal feeding and lactation-induced hyperphagia become dependent on AgRP neurons in adulthood. We also show that constitutive inactivation of Npy and Agrp genes does not prevent pregnancy or lactation, nor does it protect lactating dams from diphtheria toxin-induced starvation. Copyright © 2008 by The Endocrine Society.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=38549159128&origin=inward; http://dx.doi.org/10.1210/en.2007-1153; http://www.ncbi.nlm.nih.gov/pubmed/17974621; https://academic.oup.com/endo/article/149/2/544/2454818; https://dx.doi.org/10.1210/en.2007-1153; https://academic.oup.com/endo/article-abstract/149/2/544/2454818?redirectedFrom=fulltext
The Endocrine Society
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