Neuroendocrine causes of amenorrhea - An update
Journal of Clinical Endocrinology and Metabolism, ISSN: 1945-7197, Vol: 100, Issue: 3, Page: 812-824
2015
- 119Citations
- 271Captures
- 3Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations119
- Citation Indexes119
- 119
- CrossRef39
- Captures271
- Readers271
- 271
- Mentions3
- News Mentions2
- 2
- References1
- 1
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Review Description
Context: Secondary amenorrhea - the absence of menses for three consecutive cycles - affects approximately 3-4% of reproductive age women, and infertility - the failure to conceive after 12 months of regular intercourse - affects approximately 6-10%. Neuroendocrine causes of amenorrhea and infertility, including functional hypothalamic amenorrhea and hyperprolactinemia, constitute a majority of these cases. Objective: In this review, we discuss the physiologic, pathologic, and iatrogenic causes of amenorrhea and infertility arising from perturbations in the hypothalamic-pituitary-adrenal axis, including potential genetic causes. We focus extensively on the hormonal mechanisms involved in disrupting the hypothalamic-pituitary-ovarian axis. Conclusions: A thorough understanding of the neuroendocrine causes of amenorrhea and infertility is critical for properly assessing patients presenting with these complaints. Prompt evaluation and treatment are essential to prevent loss of bone mass due to hypoestrogenemia and/or to achieve the time-sensitive treatment goal of conception.
Bibliographic Details
The Endocrine Society
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