Effect of Vitamin D Supplementation on Muscle Function in Patients With I131-Induced Hypothyroidism: A Pilot Randomized Trial
Journal of the Endocrine Society, ISSN: 2472-1972, Vol: 8, Issue: 6, Page: bvae072
2024
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Most Recent News
Study Findings on Hypothyroidism Detailed by a Researcher at Chiang Mai University (Effect of vitamin D supplementation on muscle function in I131-induced hypothyroidism patients: A pilot randomized trial)
2024 APR 30 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Diabetes Daily -- New study results on hypothyroidism have been published. According
Article Description
Background: There is a lack of data regarding the effect of vitamin D supplements in patients with I131-induced hypothyroidism. The primary aim of this study was to investigate the effect of vitamin D supplements on muscle function, and the secondary aim was to observe the effect on body composition, insulin resistance, and quality of life (QOL) in patients with I131-induced hypothyroidism. Methods: In this pilot randomized placebo-controlled trial, patients with I131-induced hypothyroidism on a stable dose of levothyroxine were enrolled and allocated into 2 groups to receive oral vitamin D 20 000 IU weekly or placebo for 24 weeks. Baseline biochemical values, body composition, handgrip strength, the 5 times sit-to-stand test (5TSTS), homeostatic model assessment for insulin resistance (HOMA-IR), and QOL were measured before intervention and after 3 and 6 months in both groups. Mixed model regression analysis was used to compare the outcomes between the 2 groups. Significance was set at P value of < .05. Results: There were 20 participants in each group. The time taken for 5TSTS in the vitamin D group was significantly lower than the placebo group at 3 (P = .032) and 6 months (P = .006). Other outcomes, including handgrip strength, body composition, HOMA-IR, and QOL, showed no significant difference between the 2 groups. Conclusion: A supplement of vitamin D2 at 20 000 IU per week for 24 weeks could help improve performance in 5TSTS in patients with I131-induced hypothyroidism.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85192143042&origin=inward; http://dx.doi.org/10.1210/jendso/bvae072; http://www.ncbi.nlm.nih.gov/pubmed/38686391; https://academic.oup.com/jes/article/doi/10.1210/jendso/bvae072/7646011; https://dx.doi.org/10.1210/jendso/bvae072; https://academic.oup.com/jes/article/8/6/bvae072/7646011
The Endocrine Society
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