Quercetin does not alter lipopolysaccharide-induced fever in rats
Journal of Pharmacy and Pharmacology, ISSN: 0022-3573, Vol: 60, Issue: 3, Page: 357-362
2008
- 12Citations
- 16Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations12
- Citation Indexes12
- 12
- CrossRef8
- Captures16
- Readers16
- 16
Article Description
Fever is considered an important component of the acute phase response of the body in defence against invading organisms such as bacteria. Quercetin, an important representative of the flavonoid class, has been extensively studied as an anti-inflammatory agent. In the present study, we investigated the effect of quercetin, administered orally (5, 25 and 50 mg kg) or intraperitoneally (50 mg kg), on the febrile response induced by either intraperitoneally (50 μg kg) or intravenously (5 μg kg) injected lipopolysaccharide (LPS from Escherichia coli) in rats. In contrast with the well known anti-inflammatory activity of quercetin, the results demonstrate that quercetin, at the doses used, did not alter the fever induced by LPS, regardless of the route of administration. © 2008 The Authors.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=39449104617&origin=inward; http://dx.doi.org/10.1211/jpp.60.3.0011; http://www.ncbi.nlm.nih.gov/pubmed/18284816; https://academic.oup.com/jpp/article/60/3/357/6148010; https://dx.doi.org/10.1211/jpp.60.3.0011; https://academic.oup.com/jpp/article-abstract/60/3/357/6148010?redirectedFrom=fulltext
Oxford University Press (OUP)
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