The pharmacokinetics of antofloxacin in renally impaired rats

Our aim was to investigate whether renal impairment induced by cisplatin altered the pharmacokinetics of antofloxacin. Antofloxacin (7.5 mg kg , i.v.) was given to normal or renally impaired rats (induced by cisplatin). Concentrations of antofloxacin in plasma and urine were measured using HPLC. Pharmacokinetic parameters were estimated. The plasma concentrations of antofloxacin in the renally impaired rats were significantly higher than those in the normal rats, accompanied by significant increase of the area under the plasma concentration-time curve (AUC) (968.78 ± 259.39 μg min mL versus 509.84 ± 46.19 μg min mL in normal rats P < 0.05). The system clearance (CL) and renal clearance (CL ) of antofloxacin decreased from 12.66 ± 1.15 mL kg min and 3.21 ± 1.80 mLkg min in normal rats, to 6.63 ± 2.82 mL kg min and 0.31 ± 0.15 mLkg min, respectively. No differences between two treatments in half-life and mean residence time were found. We concluded that renal impairment induced by cisplatin significantly altered the pharmacokinetics of antofloxacin and resulted in decrease of the renal elimination. © 2008 The Authors.