Langerhans cell histiocytosis of the optic chiasm: Case report
Neurosurgery, ISSN: 0148-396X, Vol: 68, Issue: 2, Page: E556-61
2011
- 13Citations
- 20Captures
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Metrics Details
- Citations13
- Citation Indexes13
- CrossRef13
- 10
- Captures20
- Readers20
- 20
Article Description
BACKGROUND AND IMPORTANCE: Langerhans cell histiocytosis (LCH) is an uncommon disease, usually affecting the cranium and peripheral bones. We present a rare case of isolated optic chiasm involvement by LCH to highlight the importance of considering LCH in the differential diagnosis of optic chiasm lesions. CLINICAL PRESENTATION: A 71-year-old woman presented with a 6-week history of worsening peripheral vision, headaches, weakness, cold sensitivity, and fatigue. She was found to have dense bitemporal hemianopsia. Magnetic resonance imaging revealed a 2-cm lesion, contrast enhancing on T1 and bright on T2 signal, involving the optic chiasm but not the pituitary gland. Preoperative considerations included optic nerve glioma, choristoma of the stalk, sarcoid, hypothalamic glioma, and Langerhans cell histiocytosis. The patient underwent a right subfrontal craniotomy for biopsy of the lesion. The optic chiasm was grossly enlarged with no tissue external to the chiasm. A midline incision was made in the lamina terminalis, and multiple biopsies were taken of firm fibrous material. Histologically, the tumor was characteristic for LCH and included a mixture of histiocytes with features of Langerhans cells, eosinophils, small lymphocytes, macrophages, neutrophils, and plasma cells. CONCLUSION: LCH is a rare disease, generally affecting bone, skin, lymph nodes, and in more severe cases, visceral organs. LCH involving the optic pathways is a rare condition that should be included in the differential for adults with mass lesions involving the orbit, eye, optic nerve, or chiasm. Future clinical and basic science research is needed to better understand LCH, its molecular origin, and its growth pattern. Copyright © 2011 by the Congress of Neurological Surgeons.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79951675229&origin=inward; http://dx.doi.org/10.1227/neu.0b013e31820206c7; http://www.ncbi.nlm.nih.gov/pubmed/21135729; https://academic.oup.com/neurosurgery/article-lookup/doi/10.1227/NEU.0b013e31820206c7; http://academic.oup.com/neurosurgery/article-pdf/68/2/E556/16849800/00006123-201102000-00040.pdf; https://journals.lww.com/00006123-201102000-00040; https://dx.doi.org/10.1227/neu.0b013e31820206c7; https://academic.oup.com/neurosurgery/article/68/2/E556/2606350
Oxford University Press (OUP)
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