Accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca pump SERCA1
Development, ISSN: 0950-1991, Vol: 131, Issue: 21, Page: 5457-5468
2004
- 70Citations
- 68Captures
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Metrics Details
- Citations70
- Citation Indexes70
- 70
- CrossRef55
- Captures68
- Readers68
- 68
Article Description
When wild-type zebrafish embryos are touched at 24 hours post-fertilization (hpf), they typically perform two rapid alternating coils of the tail. By contrast, accordion (acc) mutants fail to coil their tails normally but contract the bilateral trunk muscles simultaneously to shorten the trunk, resulting in a pronounced dorsal bend. Electrophysiological recordings from muscles showed that the output from the central nervous system is normal in mutants, suggesting a defect in muscles is responsible. In fact, relaxation in acc muscle is significantly slower than normal. In vivo imaging of muscle Ca transients revealed that cytosolic Ca decay was significantly slower in acc muscle. Thus, it appears that the mutant behavior is caused by a muscle relaxation defect due to the impairment of Ca re-uptake. Indeed, acc mutants carry a mutation in atp2a1 gene that encodes the sarco(endo)plasmic reticulum Ca-ATPase 1 (SERCA1), a Ca pump found in the muscle sarcoplasmic reticulum (SR) that is responsible for pumping Ca from the cytosol back to the SR. As SERCA1 mutations in humans lead to Brody disease, an exercise-induced muscle relaxation disorder, zebrafish accordion mutants could be a useful animal model for this condition.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=9444250520&origin=inward; http://dx.doi.org/10.1242/dev.01410; http://www.ncbi.nlm.nih.gov/pubmed/15469975; https://journals.biologists.com/dev/article/131/21/5457/42370/accordion-a-zebrafish-behavioral-mutant-has-a; https://dx.doi.org/10.1242/dev.01410; https://dev.biologists.org/content/131/21/5457
The Company of Biologists
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