Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals
Development, ISSN: 0950-1991, Vol: 135, Issue: 22, Page: 3643-3653
2008
- 55Citations
- 60Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations55
- Citation Indexes55
- 55
- CrossRef52
- Captures60
- Readers60
- 60
- Mentions1
- References1
- Wikipedia1
Article Description
Longitudinal axons transmit all signals between the brain and spinal cord. Their axon tracts through the brain stem are established by a simple set of pioneer axons with precise trajectories parallel to the floor plate. To identify longitudinal guidance mechanisms in vivo, the overall role of floor plate tissue and the specific roles of Slit/Robo signals were tested. Ectopic induction or genetic deletion of the floor plate diverted longitudinal axons into abnormal trajectories. The expression patterns of the diffusible cues of the Slit family were altered in the floor plate experiments, suggesting their involvement in longitudinal guidance. Genetic tests of Slit1 and Slit2, and the Slit receptors Robo1 and Robo2 were carried out in mutant mice. Slit1;Slit2 double mutants had severe longitudinal errors, particularly for ventral axons, including midline crossing and wandering longitudinal trajectories. Robo1 and Robo2 were largely genetically redundant, and neither appeared to specify specific tract positions. However, combined Robo1 and Robo2 mutations strongly disrupted each pioneer tract. Thus, pioneer axons depend on long-range floor plate cues, with Slit/Robo signaling required for precise longitudinal trajectories.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=59149092374&origin=inward; http://dx.doi.org/10.1242/dev.023325; http://www.ncbi.nlm.nih.gov/pubmed/18842816; https://journals.biologists.com/dev/article/135/22/3643/76426/Pioneer-longitudinal-axons-navigate-using-floor; https://dx.doi.org/10.1242/dev.023325; https://dev.biologists.org/content/135/22/3643
The Company of Biologists
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