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An emerging role for TOR signaling in mammalian tissue and stem cell physiology

Development, ISSN: 0950-1991, Vol: 138, Issue: 16, Page: 3343-3356
2011
  • 116
    Citations
  • 0
    Usage
  • 158
    Captures
  • 3
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    116
  • Captures
    158
  • Mentions
    3
    • References
      2
      • Wikipedia
        2
    • News Mentions
      1
      • News
        1

Most Recent News

Mammalian target of rapamycin pathway is up-regulated by both acute endurance exercise and chronic muscle contraction in rat skeletal muscle

  Introduction            Skeletal muscle responds to periods of chronic contractile activity by increasing mitochondrial content, thereby improving fatigue resistance and contractile performance (Holloszy and Coyle 1984).

Review Description

The mammalian target of rapamycin (mTOR) is a kinase that responds to a myriad of signals, ranging from nutrient availability and energy status, to cellular stressors, oxygen sensors and growth factors. The finely tuned response of mTOR to these stimuli results in alterations to cell metabolism and cell growth. Recent studies of conditional knockouts of mTOR pathway components in mice have affirmed the role of mTOR signaling in energy balance, both at the cell and whole organism levels. Such studies have also highlighted a role for mTOR in stem cell homeostasis and lifespan determination. Here, we discuss the molecular mechanisms of TOR signaling and review recent in vitro and in vivo studies of mTOR tissuespecific activities in mammals. © 2011. Published by The Company of Biologists Ltd.

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