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Tudor domain proteins in development

Development (Cambridge), ISSN: 0950-1991, Vol: 139, Issue: 13, Page: 2255-2266
2012
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Article Description

Tudor domain proteins function as molecular adaptors, binding methylated arginine or lysine residues on their substrates to promote physical interactions and the assembly of macromolecular complexes. Here, we discuss the emerging roles of Tudor domain proteins during development, most notably in the Piwi-interacting RNA pathway, but also in other aspects of RNA metabolism, the DNA damage response and chromatin modification. © 2012.

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