Nkx genes are essential for maintenance of ventricular identity
Development (Cambridge), ISSN: 0950-1991, Vol: 140, Issue: 20, Page: 4203-4213
2013
- 80Citations
- 108Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations80
- Citation Indexes80
- 80
- CrossRef61
- Captures108
- Readers108
- 108
Article Description
Establishment of specific characteristics of each embryonic cardiac chamber is crucial for development of a fully functional adult heart. Despite the importance of defining and maintaining unique features in ventricular and atrial cardiomyocytes, the regulatory mechanisms guiding these processes are poorly understood. Here, we show that the homeodomain transcription factors Nkx2.5 and Nkx2.7 are necessary to sustain ventricular chamber attributes through repression of atrial chamber identity. Mutation of nkx2.5 in zebrafish yields embryos with diminutive ventricular and bulbous atrial chambers. These chamber deformities emerge gradually during development, with a severe collapse in the number of ventricular cardiomyocytes and an accumulation of excess atrial cardiomyocytes as the heart matures. Removal of nkx2.7 function from nkx2.5 mutants exacerbates the loss of ventricular cells and the gain of atrial cells. Moreover, in these Nkx-deficient embryos, expression of vmhc, a ventricular gene, fades, whereas expression of amhc, an atrial gene, expands. Cell-labeling experiments suggest that ventricular cardiomyocytes can transform into atrial cardiomyocytes in the absence of Nkx gene function. Through suggestion of transdifferentiation from ventricular to atrial fate, our data reveal a pivotal role for Nkx genes in maintaining ventricular identity and highlight remarkable plasticity in differentiated myocardium. Thus, our results are relevant to the etiologies of fetal and neonatal cardiac pathology and could direct future innovations in cardiac regenerative medicine. © 2013. Published by The Company of Biologists Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84884934231&origin=inward; http://dx.doi.org/10.1242/dev.095562; http://www.ncbi.nlm.nih.gov/pubmed/24026123; https://journals.biologists.com/dev/article/140/20/4203/45907/Nkx-genes-are-essential-for-maintenance-of; https://dx.doi.org/10.1242/dev.095562; https://dev.biologists.org/content/140/20/4203; http://dev.biologists.org/cgi/doi/10.1242/dev.095562; http://dev.biologists.org/content/140/20/4203; http://dev.biologists.org/content/140/20/4203.abstract; http://dev.biologists.org/content/140/20/4203.full.pdf; http://dev.biologists.org/lookup/doi/10.1242/dev.095562; https://dev.biologists.org/content/140/20/4203.abstract; https://dev.biologists.org/content/develop/140/20/4203.full.pdf
The Company of Biologists
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