PlumX Metrics
Embed PlumX Metrics

A local Wnt-3a signal is required for development of the mammalian hippocampus

Development, ISSN: 0950-1991, Vol: 127, Issue: 3, Page: 457-467
2000
  • 530
    Citations
  • 0
    Usage
  • 289
    Captures
  • 3
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    530
  • Captures
    289
  • Mentions
    3
    • References
      2
      • Wikipedia
        2
    • Blog Mentions
      1
      • Blog
        1

Article Description

The mechanisms that regulate patterning and growth of the developing cerebral cortex remain unclear. Suggesting a role for Wnt signaling in these processes, multiple Wnt genes are expressed in selective patterns in the embryonic cortex. We have examined the role of Wnt-3a signaling at the caudomedial margin of the developing cerebral cortex, the site of hippocampal development. We show that Wnt3a acts locally to regulate the expansion of the caudomedial cortex, from which the hippocampus develops. In mice lacking Wnt-3a, caudomedial cortical progenitor cells appear to be specified normally, but then underproliferate. By mid-gestation, the hippocampus is missing or represented by tiny populations of residual hippocampal cells. Thus, Wnt3a signaling is crucial for the normal growth of the hippocampus. We suggest that the coordination of growth with patterning may be a general role for Wnts during vertebrate development.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know