Defining specificity of transcription factor regulatory activities
Journal of Cell Science, ISSN: 0021-9533, Vol: 122, Issue: 22, Page: 4027-4034
2009
- 21Citations
- 77Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations21
- Citation Indexes21
- 21
- CrossRef19
- Captures77
- Readers77
- 77
Article Description
Mammalian transcription factors (TFs) are often involved in differential cell-type- and context-specific transcriptional responses. Recent large-scale comparative studies of TF recruitment to the genome, and of chromatin structure and gene expression, have allowed a better understanding of the general rules that underlie the differential activities of a given TF. It has emerged that chromatin structure dictates the differential binding of a given TF to cell-type-specific cis-regulatory elements. The subsequent regulation of TF activity then ensures the functional activation of only the precise subset of all regulatory sites bound by the TF that are required to mediate appropriate gene expression. Ultimately, the organization of the genome within the nucleus, and crosstalk between different cis-regulatory regions involved in gene regulation, also participate in establishing a specific transcriptional program. In this Commentary, we discuss how the integration of these different and probably intimately linked regulatory mechanisms allow for TF cell-type- and context-specific modulation of gene expression.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70849109085&origin=inward; http://dx.doi.org/10.1242/jcs.054916; http://www.ncbi.nlm.nih.gov/pubmed/19910494; https://journals.biologists.com/jcs/article/122/22/4027/31006/Defining-specificity-of-transcription-factor; https://dx.doi.org/10.1242/jcs.054916; https://jcs.biologists.org/content/122/22/4027
The Company of Biologists
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