The lysine demethylase LSD1 is required for nuclear envelope formation at the end of mitosis
Journal of Cell Science, ISSN: 1477-9137, Vol: 128, Issue: 18, Page: 3466-3477
2015
- 26Citations
- 44Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations26
- Citation Indexes26
- 26
- CrossRef21
- Captures44
- Readers44
- 44
Article Description
The metazoan nucleus breaks down and reassembles during each cell division. Upon mitotic exit, the successful reestablishment of an interphase nucleus requires the coordinated reorganization of chromatin and formation of a functional nuclear envelope. Here, we report that the histone demethylase LSD1 (also known as KDM1A) plays a crucial role in nuclear assembly at the end of mitosis. Downregulation of LSD1 in cells extends telophase and impairs nuclear pore complex assembly. In vitro, LSD1 demethylase activity is required for the recruitment of MEL28 (also known as ELYS and AHCTF1) and nuclear envelope precursor vesicles to chromatin, crucial steps in nuclear reassembly. Accordingly, the formation of a closed nuclear envelope and nuclear pore complex assembly are impaired upon depletion of LSD1 or inhibition of its activity. Our results identify histone demethylation by LSD1 as a new regulatory mechanism linking the chromatin state and nuclear envelope formation at the end of mitosis.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84946043150&origin=inward; http://dx.doi.org/10.1242/jcs.173013; http://www.ncbi.nlm.nih.gov/pubmed/26224877; https://journals.biologists.com/jcs/article/doi/10.1242/jcs.173013/259922/The-lysine-demethylase-LSD1-is-required-for; https://dx.doi.org/10.1242/jcs.173013; https://jcs.biologists.org/content/128/18/3466
The Company of Biologists
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