Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein
Journal of Cell Science, ISSN: 1477-9137, Vol: 132, Issue: 2
2019
- 24Citations
- 23Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations24
- Citation Indexes24
- 24
- CrossRef19
- Captures23
- Readers23
- 23
- Mentions1
- Blog Mentions1
- Blog1
Article Description
Centriolar satellites are small cytoplasmic granules that play important roles in regulating the formation of centrosomes and primary cilia. Ubiquitylation of satellite proteins, including the core satellite scaffold protein pericentriolar material 1 (PCM1), regulates centriolar satellite integrity. Currently, deubiquitylases that control centriolar satellite integrity have not been identified. In this study, we find that the deubiquitylase USP9X binds PCM1, and antagonizes PCM1 ubiquitylation to protect it from proteasomal degradation. Knockdown of USP9X in human cell lines reduces PCM1 protein levels, disrupts centriolar satellite particles and causes localization of satellite proteins, such as CEP290, to centrosomes. Interestingly, knockdown of mindbomb 1 (MIB1), a ubiquitin ligase that promotes PCM1 ubiquitylation and degradation, in USP9X-depleted cells largely restores PCM1 protein levels and corrects defects caused by the loss of USP9X. Overall, our study reveals that USP9X is a constituent of centriolar satellites and functions to maintain centriolar satellite integrity by stabilizing PCM1.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85060366011&origin=inward; http://dx.doi.org/10.1242/jcs.221663; http://www.ncbi.nlm.nih.gov/pubmed/30584065; https://journals.biologists.com/jcs/article/132/2/jcs221663/41/Deubiquitylase-USP9X-maintains-centriolar; https://dx.doi.org/10.1242/jcs.221663; https://jcs.biologists.org/content/132/2/jcs221663
The Company of Biologists
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