A novel 14-3-3 gene is osmoregulated in gill epithelium of the euryhaline teleost Fundulus heteroclitus
Journal of Experimental Biology, ISSN: 0022-0949, Vol: 204, Issue: 17, Page: 2975-2985
2001
- 58Citations
- 47Captures
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Metrics Details
- Citations58
- Citation Indexes58
- 58
- CrossRef8
- Captures47
- Readers47
- 47
Article Description
We have cloned and analyzed the full-length coding sequence and 3′ untranslated region (UTR) of a unique 14-3-3 gene of the euryhaline teleost Fundulus heteroclitus, which we named 14-3-3.a. Phylogenetic analysis of the deduced amino acid sequence revealed that the 14-3-3.a gene product is most similar to vertebrate 14-3-3ζ and β, yet it displays considerable divergence to known classes of vertebrate 14-3-3 isoforms. The N and C termini of 14-3-3.a are the most unique regions, whereas the amino acid residues forming the amphipathic ligand-binding groove are highly conserved. F. heteroclitus 14-3-3.a mRNA expression is high in gill epithelium, moderate in intestine and brain, and low in gonads, white muscle and heart. Because 14-3-3 proteins are important molecular scaffolds and cofactors for phosphoproteins and signaling complexes, the high level of 14-3-3.a expression in gill epithelium of the euryhaline teleost F. heteroclitus suggests that it is crucial for signal transduction in gill epithelial cells. We provide evidence that 14-3-3.a is involved in osmosensory signal transduction by showing that its mRNA and protein levels in gill epithelium, but not in any other tissue analyzed, increase two- to fourfold within 24 h of salinity transfer of fish from sea water to fresh water. These data are clear evidence for an important role of 14-3-3.a in the remodeling of gill epithelium during transition of euryhaline fish between plasma-hyperosmotic and plasma-hyposmotic environments.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035746265&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11551986; http://dx.doi.org/10.1242/jeb.204.17.2975; https://journals.biologists.com/jeb/article/204/17/2975/32837/A-novel-14-3-3-gene-is-osmoregulated-in-gill; http://journals.biologists.com/jeb/article-pdf/204/17/2975/1238283/2975.pdf
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