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β-1.3 Glucan Complex Drastically Suppresses Kidney Clearance of siRNA

Chemistry Letters, ISSN: 1348-0715, Vol: 50, Issue: 10, Page: 1778-1780
2021
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Article Description

siRNA was complexed with a β-1,3-glucan schizophyllan and intravenously administrated into mice. The complexed siRNA escaped renal excretion and remained in the blood. The monocytes in spleen were found to capture the complex and cause the longer residence time of the complexed siRNA, as well as increased size of the complex.

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