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Calixarene-based Cage Compound: Synthesis via Simple Condensation of t-Butylcalix[4]arene with α,ω-Dibromoacetate and Inclusion Complex Formation with Phenol

Chemistry Letters, ISSN: 1348-0715, Vol: 52, Issue: 12, Page: 883-886
2023
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Article Description

Reaction of p-t-butylcalix[4]arene (BCA[4]) with α,ωdibromoacetate (DBH) afforded a soluble cage compound, BCA[4]-DBH, in high yield. Single-crystal X-ray analysis revealed that BCA[4]-DBH contains a fixed cavity. Examination of host-guest chemistry showed that BCA[4]-DBH forms a 1:1 inclusion complex with phenol, with an association constant (K) of 34.

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