Ameliorative potential of pralidoxime in tibial and sural nerve transection-induced neuropathic pain in rats
Biological and Pharmaceutical Bulletin, ISSN: 0918-6158, Vol: 33, Issue: 8, Page: 1331-1336
2010
- 5Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations5
- Citation Indexes5
- CrossRef5
- Captures12
- Readers12
- 12
Article Description
The present study was designed to investigate the ameliorative potential of pralidoxime in tibial and sural nerve transection-induced neuropathy in rats. Tibial and sural nerve transection was performed by sectioning tibial and sural nerve portions (2 mm) of the sciatic nerve, and leaving the common peroneal nerve intact. The pinprick, acetone, hot and cold tail immersion tests were performed to assess the degree of motor functions, mechanical hyperalgesia, cold allodynia, heat and cold hyperalgesia respectively. Biochemically, the tissue thio-barbituric acid reactive species (TBARS), super-oxide anion contents (the markers of oxidative stress) and total calcium levels were measured. Tibial sural nerve transection resulted in the development of mechanical hyperalgesia, cold allodynia, heat and cold hyperalgesia along with the rise in oxidative stress and calcium levels. However, administration of pralidoxime (10, 20 mg/kg intraperitoneally (i.p.)) for 14 d attenuated tibial and sural nerve transection-induced cold allodynia, mechanical, hot and cold hyperalgesia. Furthermore, pralidoxime also attenuated tibial and sural nerve transection induced increase in oxidative stress and calcium levels. It may be concluded that pralidoxime has ameliorative potential in attenuating the painful neuropathic state associated with tibial and sural nerve transection, which may possibly be attributed to decrease in oxidative stress and calcium levels. © 2010 Pharmaceutical Society of Japan.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77956123472&origin=inward; http://dx.doi.org/10.1248/bpb.33.1331; http://www.ncbi.nlm.nih.gov/pubmed/20686227; http://www.jstage.jst.go.jp/article/bpb/33/8/33_8_1331/_article; https://www.jstage.jst.go.jp/article/bpb/33/8/33_8_1331/_article/-char/en/; https://www.jstage.jst.go.jp/article/bpb/33/8/33_8_1331/_article/-char/ja/; https://dx.doi.org/10.1248/bpb.33.1331; https://www.jstage.jst.go.jp/article/bpb/33/8/33_8_1331/_article
Pharmaceutical Society of Japan
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