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Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs

Biological and Pharmaceutical Bulletin, ISSN: 0918-6158, Vol: 35, Issue: 8, Page: 1295-1299
2012
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Article Description

We have synthesized new 10-hydroxycamptothecin (HCPT) analogs and evaluated their anticancer activity in cell culture and in experimental animal tumor model. Although the new analogs were less potent against L1210 leukemia cells in vitro, some of them were more efficacious against L1210 leukemia in vivo compared to the parent HCPT. © 2012 The Pharmaceutical Society of Japan.

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