Function follows form ― a review of cardiac cell therapy ―
Circulation Journal, ISSN: 1347-4820, Vol: 83, Issue: 12, Page: 2399-2412
2019
- 42Citations
- 73Captures
- 4Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations42
- Citation Indexes42
- 42
- CrossRef26
- Captures73
- Readers73
- 73
- Mentions4
- News Mentions4
- News4
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Review Description
The investment of nearly 2 decades of clinical investigation into cardiac cell therapy has yet to change cardiovascular practice. Recent insights into the mechanism of cardiac regeneration help explain these results and provide important context in which we can develop next-generation therapies. Non-contractile cells such as bone marrow or adult heart derivatives neither engraft long-term nor induce new muscle formation. Correspondingly, these cells offer little functional benefit to infarct patients. In contrast, preclinical data indicate that transplantation of bona fide cardiomyocytes derived from pluripotent stem cells induces direct remuscularization. This new myocardium beats synchronously with the host heart and induces substantial contractile benefits in macaque monkeys, suggesting that regeneration of contractile myocardium is required to fully recover function. Through a review of the preclinical and clinical trials of cardiac cell therapy, distinguishing the primary mechanism of benefit as either contractile or non-contractile helps appreciate the barriers to cardiac repair and establishes a rational path to optimizing therapeutic benefit.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85075792836&origin=inward; http://dx.doi.org/10.1253/circj.cj-19-0567; http://www.ncbi.nlm.nih.gov/pubmed/31723070; https://www.jstage.jst.go.jp/article/circj/83/12/83_CJ-19-0567/_article; https://dx.doi.org/10.1253/circj.cj-19-0567; https://www.jstage.jst.go.jp/article/circj/83/12/83_CJ-19-0567/_article/-char/en/; https://www.jstage.jst.go.jp/article/circj/83/12/83_CJ-19-0567/_article/-char/ja/
Japanese Circulation Society
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