Significance of pericardial cytokines in giant cell myocarditis in rats - Pathological comparison to viral myocarditis in mice
Japanese Circulation Journal, ISSN: 0047-1828, Vol: 64, Issue: 12, Page: 977-981
2000
- 5Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations5
- Citation Indexes5
- CrossRef4
- Captures4
- Readers4
Article Description
To investigate the precise disease progression in myocarditis, Lewis rats were injected with porcine cardiac myosin, and C3H/He mice were inoculated with coxsackievirus B3. Both were killed serially, and the hearts were stained with hematoxyline-eosin to compare their pathological characteristics. In viral myocarditis, viral replication in the myocardium resulted in myocardial necrosis with inflammation, and the lesions were distributed transmurally, as previously reported. On the other hand, in giant cell myocarditis, inflammatory lesions appeared at first around the capillaries in the epicardium, and thereafter spread transmurally. Pericardial effusion was noticed in all the rats with myocarditis in the fulminant stage. Levels of interleukin (IL) -1β and IL-6 in the pericardial effusion were elevated compared with the serum cytokines at the peak of inflammation. However, interferon-γ in both the pericardial effusion and serum was not elevated. The cause of the myocardial lesions that developed in rats with giant cell myocarditis may be some active inflammatory process via the pericardial effusion.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033637421&origin=inward; http://dx.doi.org/10.1253/jcj.64.977; http://www.ncbi.nlm.nih.gov/pubmed/11194294; http://www.jstage.jst.go.jp/article/jcj/64/12/64_12_977/_article; https://dx.doi.org/10.1253/jcj.64.977; https://www.jstage.jst.go.jp/article/jcj/64/12/64_12_977/_article
Japanese Circulation Society
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