Pharmacological Profiles of Aspergillomarasmines as Endothelin Converting Enzyme Inhibitors
Japanese Journal of Pharmacology, ISSN: 0021-5198, Vol: 63, Issue: 2, Page: 187-193
1993
- 28Citations
- 15Captures
- 1Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations28
- Citation Indexes28
- 28
- CrossRef22
- Captures15
- Readers15
- 15
- Mentions1
- References1
- Wikipedia1
Article Description
Aspergillomarasmine-A and-B (AM-A and -B), which were isolated from the cultured broth of an unidentified fungus N877, showed apparent inhibition against endothelin-converting enzyme (ECE) from bovine endothelial cells as measured by the formation of endothelin-1 (ET-1) converted from big endothelin-1 (bET-1), with IC 50 values of 3.4 and 2.5 μ M for AM-A and -B, respectively. EDTA also inhibited ECE (IC 50 =1.1 μ M ), but the inhibitions by AM-A, AM-B and EDTA were each abolished by the addition of 10 μ Μ Zn 2+ to the reaction mixture. In mice, AM-A and -B dose-dependently (10-50 mg/kg, i.v.) caused significant prolongation of the latency to sudden death induced by i.v. bET-1 (25 nmol/kg), but not that by ET-1 (5 nmol/kg), accompanied by a decrease in plasma immunoreactive ET-1 formation, while EDTA (24 mg/kg) failed to do so. In mice, the LD 50 value of AM-A was calculated to be 159.8 mg/kg, i.v., which was much larger than that of EDTA (28.5 mg/kg, i.v.), indicating the low toxicity of AM-A. AM-A (30 mg/kg, i.v.) also suppressed bET-1-induced hemoconcentration and hypertension in mice and rats, respectively. These findings suggest that although ECE inhibition by AM-A was mainly attributable to its chelating activity, it showed apparent in vivo activities due to ECE inhibition with low toxicity.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021519819359542; http://dx.doi.org/10.1254/jjp.63.187; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027376817&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/8283829; https://linkinghub.elsevier.com/retrieve/pii/S0021519819359542; https://dx.doi.org/10.1254/jjp.63.187; https://www.jstage.jst.go.jp/article/jphs1951/63/2/63_2_187/_article
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know