Lipid Peroxidation in the Pancreas and Other Organs in Streptozotocin Diabetic Rats
Japanese Journal of Pharmacology, ISSN: 0021-5198, Vol: 75, Issue: 3, Page: 267-273
1997
- 44Citations
- 17Captures
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Metrics Details
- Citations44
- Citation Indexes44
- 44
- CrossRef28
- Captures17
- Readers17
- 12
Article Description
We studied the relationship between changes in lipid peroxides and those in catalase activity in pancreases, livers and hearts of streptozotocin-induced diabetic rats. Animals were killed 2 or 7 weeks after saline or streptozotocin (32 mg/kg, i.v.) injection. The levels of blood glucose and plasma insulin in the 2-week streptozotocin-treated rats were 176.8±20.5 mg/dl and 29.9±3.2 μ U/ml, respectively. In the pancreas, the lipid peroxide level significantly decreased and the catalase activity significantly increased 2 weeks after streptozotocin injection. These changes recovered after 7 weeks. In the heart, the lipid peroxide level significantly increased without any change of catalase activity 2 weeks after the initiation of diabetes. After 7 weeks, the catalase activity significantly increased and the lipid peroxide level returned to the control level. In the liver, there was no change in the lipid peroxides and catalase in the 2-week streptozotocin-treated rats, whereas the catalase activity significantly increased 7 weeks after the injection. It was suggested that the defense system in the pancreas to oxidative stress may be evoked in an early stage of streptozotocin-induced diabetes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021519819313058; http://dx.doi.org/10.1254/jjp.75.267; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0031463481&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9434258; https://linkinghub.elsevier.com/retrieve/pii/S0021519819313058; https://dx.doi.org/10.1254/jjp.75.267
Elsevier BV
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