Effects of SA13353, a Transient Receptor Potential Vanilloid 1 Agonist, on Leukocyte Infiltration in Lipopolysaccharide-Induced Acute Lung Injury and Ovalbumin-Induced Allergic Airway Inflammation
Journal of Pharmacological Sciences, ISSN: 1347-8613, Vol: 112, Issue: 4, Page: 487-490
2010
- 20Citations
- 20Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations20
- Citation Indexes20
- CrossRef20
- 20
- Captures20
- Readers20
- 20
Article Description
We recently demonstrated that SA13353, a transient receptor potential vanilloid 1 (TRPV1) agonist, reduced the severity of the symptoms of kidney injury, arthritis, and encephalomyelitis in disease models. Here, we investigated the effects of orally administered SA13353 on leukocyte infiltration in lipopolysaccharide (LPS)-induced acute lung injury and ovalbumin-induced allergic airway inflammation. In LPS-induced lung injury, SA13353 attenuated neutrophil infiltration and the increase of TNF- α and CINC-1 levels. In allergic airway inflammation, SA13353 tended to inhibit leukocyte infiltration and attenuated the increase of IL-4 and IL-12p40. These results suggest that somatosensory TRPV1 may play an anti-inflammatory role in lung inflammation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1347861319309880; http://dx.doi.org/10.1254/jphs.09295sc; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77951218847&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/20351486; http://www.jstage.jst.go.jp/article/jphs/112/4/112_09295SC/_article; https://www.jstage.jst.go.jp/article/jphs/112/4/112_09295SC/_article/-char/en/; https://www.jstage.jst.go.jp/article/jphs/112/4/112_09295SC/_article/-char/ja/; https://dx.doi.org/10.1254/jphs.09295sc; https://www.jstage.jst.go.jp/article/jphs/112/4/112_09295SC/_article
Japanese Pharmacological Society
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