Effects of Millettia macrophylla (Fabaceae) Extracts on Estrogen Target Organs of Female Wistar Rat
Journal of Pharmacological Sciences, ISSN: 1347-8613, Vol: 123, Issue: 2, Page: 120-131
2013
- 16Citations
- 43Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations16
- Citation Indexes16
- 16
- CrossRef10
- Captures43
- Readers43
- 43
Article Description
The present study aims to determine the estrogenicity of Millettia macrophylla, a Cameroonian medicinal plant, in ovariectomized rats and to investigate the underlying mechanisms, in order to justify scientifically its traditional use. To accomplish this objective, we used dichloromethane (DCM) and methanol (MeOH) extracts of the stem bark of M. macrophylla. In the cell culture based assay, the MeOH extract significantly transactivated estrogen receptor α (ER α ) and estrogen receptor β (ER β ); in addition, the estrogen-like effects of both, DCM and MeOH extracts, could be inhibited in vitro by the pure ER antagonist ICI 182,780, indicating that these effects were primarily mediated through ERs. In animal experiments, both DCM and MeOH extracts significantly increased the uterine and vaginal epithelial heights in the 3-day treatment assay, while only the MeOH extract exhibited such effects in the sub-chronic treatment regimen. Furthermore, the MeOH extract significantly decreased fasting serum triglycerides, total cholesterol levels and artherogenic risk in the sub-chronic treatment. These results indicate that M. macrophylla extracts have estrogen-like effects supporting their traditional use in Cameroon to alleviate some menopausal problems (See graphical abstract in Supplementary Fig. 1, available in the online version only). [Supplementary Figures: available only at http://dx.doi.org/10.1254/jphs.13094FP ]
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1347861319302622; http://dx.doi.org/10.1254/jphs.13094fp; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84888624697&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/24077107; http://jlc.jst.go.jp/DN/JST.JSTAGE/jphs/13094FP?lang=en&from=CrossRef&type=abstract; https://www.jstage.jst.go.jp/article/jphs/123/2/123_13094FP/_pdf; https://www.jstage.jst.go.jp/article/jphs/123/2/123_13094FP/_article; https://www.jstage.jst.go.jp/article/jphs/123/2/123_13094FP/_article/-char/en/; https://www.jstage.jst.go.jp/article/jphs/123/2/123_13094FP/_article/-char/ja/; https://dx.doi.org/10.1254/jphs.13094fp
Japanese Pharmacological Society
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