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Recent advances in understanding the complexities of metastasis

F1000Research, ISSN: 2046-1402, Vol: 7
2018
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Review Description

Tumour metastasis is a dynamic and systemic process. It is no longer seen as a tumour cell-autonomous program but as a multifaceted and complex series of events, which is influenced by the intrinsic cellular mutational burden of cancer cells and the numerous bidirectional interactions between malignant and non-malignant cells and fine-tuned by the various extrinsic cues of the extracellular matrix. In cancer biology, metastasis as a process is one of the most technically challenging aspects of cancer biology to study. As a result, new platforms and technologies are continually being developed to better understand this process. In this review, we discuss some of the recent advances in metastasis and how the information gleaned is re-shaping our understanding of metastatic dissemination.

Bibliographic Details

Chitty, Jessica L.; Filipe, Elysse C.; Lucas, Morghan C.; Herrmann, David; Cox, Thomas R.; Timpson, Paul

F1000 ( Faculty of 1000 Ltd)

Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Pharmacology, Toxicology and Pharmaceutics

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