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Combating Cholera

F1000Research, ISSN: 1759-796X, Vol: 8
2019
  • 25
    Citations
  • 0
    Usage
  • 149
    Captures
  • 1
    Mentions
  • 64
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    25
  • Captures
    149
  • Mentions
    1
    • References
      1
      • 1
  • Social Media
    64
    • Shares, Likes & Comments
      64
      • Facebook
        64

Review Description

Cholera infections caused by the gamma-proteobacterium Vibrio cholerae have ravaged human populations for centuries, and cholera pandemics have afflicted every corner of the globe. Fortunately, interventions such as oral rehydration therapy, antibiotics/antimicrobials, and vaccines have saved countless people afflicted with cholera, and new interventions such as probiotics and phage therapy are being developed as promising approaches to treat even more cholera infections. Although current therapies are mostly effective and can reduce disease transmission, cholera outbreaks remain deadly, as was seen during recent outbreaks in Haiti, Ethiopia, and Yemen. This is due to significant underlying political and socioeconomic complications, including shortages of vaccines and clean food and water and a lack of health surveillance. In this review, we highlight the strengths and weaknesses of current cholera therapies, discuss emerging technologies, and argue that a multi-pronged, flexible approach is needed to continue to reduce the worldwide burden of cholera.

Bibliographic Details

Brian Y. Hsueh; Christopher M. Waters

F1000 ( Faculty of 1000 Ltd)

Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Pharmacology, Toxicology and Pharmaceutics

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