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Tumour Cell Heterogeneity

F1000Research, ISSN: 1759-796X, Vol: 5, Page: F1000 Faculty Rev-238
2016
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Review Description

The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognostication and treatment.

Bibliographic Details

Gay, Laura; Baker, Ann-Marie; Graham, Trevor A

F1000 Research Ltd

Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Pharmacology, Toxicology and Pharmaceutics

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