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Recent advances in understanding and managing chordomas

F1000Research, ISSN: 1759-796X, Vol: 5, Page: 2902
2016
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Review Description

Chordomas are rare primary bone tumors arising from embryonic remnants of the notochord. They are slow-growing, locally aggressive, and destructive and typically involve the axial skeleton. Genetic studies have identified several mutations implicated in the pathogenesis of these tumors. Treatment poses a challenge given their insidious progression, degree of local invasion at presentation, and high recurrence rate. They tend to respond poorly to conventional chemotherapy and radiation. This makes radical resection the mainstay of their treatment. Recent advances in targeted chemotherapy and focused particle beam radiation, however, have improved the management and prognosis of these tumors.

Bibliographic Details

Youssef, Carl; Aoun, Salah G; Moreno, Jessica R; Bagley, Carlos A

F1000 Research Ltd

Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Pharmacology, Toxicology and Pharmaceutics

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