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Sudachitin, a polymethoxyflavone from citrus sudachi, suppresses lipopolysaccharide-induced inflammatory responses in mouse macrophage-like RAW264 cells

Bioscience, Biotechnology and Biochemistry, ISSN: 0916-8451, Vol: 76, Issue: 3, Page: 598-600
2012
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Article Description

Although some polymethoxyflavones possess several important biological properties, including neuroprotective, anticancer, and anti-inflammatory ones, sudachitin, a polymethoxyflavone from Citrus sudachi, has been little studied. In this study, we found that sudachitin inhibited nitric oxide production by suppressing the expression of inducible nitric oxide synthase in lipopolysaccharide- stimulated macrophages, indicating that sudachitin has an anti-inflammatory effect.

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