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Luteolin inhibits endothelin-1 secretion in cultured endothelial cells

Bioscience, Biotechnology and Biochemistry, ISSN: 0916-8451, Vol: 69, Issue: 8, Page: 1613-1615
2005
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Article Description

We discovered that luteolin, a typical flavonoid contained in various kinds of plants, inhibits the secretion and gene expression of endothelin-1 (ET-1), a potent vasoconstrictor regulating blood pressure, in porcine aortic endothelial cells. Its ED was about 10 μM. In addition, the inhibition of ET-1 by a glycoside compound of luteolin (luteolin-6-C-glucoside) was weak.

Bibliographic Details

Kozakai, Takaharu; Yamanaka, Akiko; Ichiba, Toshio; Toyokawa, Tetsuya; Kamada, Yasuhiro; Tamamura, Takako; Ichimura, Toshiaki; Maruyama, Susumu

Informa UK Limited

Medicine

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